Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.69 |
| ▸ | KDR | P35968 | 5/20 | 0.69 |
| ▸ | FLT3 | P36888 | 3/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.69 |
| ▸ | CSF1R | P07333 | 2/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.69 |
| ▸ | SRC | P12931 | 2/20 | 0.69 |
| ▸ | FLT1 | P17948 | 2/20 | 0.69 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | FLT4 | P35916 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | GMNN | O75496 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475402 | 0.88 | RET (0.64) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL5475770 | 0.88 | RET (0.64) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL5475766 | 0.88 | RET (0.64) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL5475395 | 0.88 | RET (0.64) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL5470645 | 0.85 | RET (0.60) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL5470642 | 0.85 | RET (0.60) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL6320744 | 0.82 | RET (0.63) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL6328758 | 0.82 | RET (0.63) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL1395428 | 0.82 | RET (0.63) | RETKDRFLT3ALKPDGFRB | |
| SCHEMBL6765420 | 0.82 | RET (0.63) | RETKDRFLT3ALKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687506-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687506-B2 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-12 | — | — | US | disclosed |
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-12 | — | — | US | disclosed |
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| WO-2007038613-A2 | SELECTIVE SERINE/THREONINE KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082884-A1 | Selective serine/threonine kinase inhibitors | DSTYK, TTK, SBK1 | RET 425/4885KDR 1000/4885FLT3 490/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | RET 3720/4885KDR 4334/4885FLT3 4311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.