Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415667 | 0.89 | PSEN1 (0.44) | HPGDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3415665 | 0.89 | PSEN1 (0.44) | HPGDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3414043 | 0.87 | AKR1C3 (0.47) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL3414040 | 0.87 | AKR1C3 (0.47) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL3415767 | 0.84 | PPARA (0.60) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL13433357 | 0.84 | HPGD (0.47) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL13433438 | 0.83 | HPGD (0.48) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL3419218 | 0.82 | PPARA (0.51) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL3418656 | 0.82 | KDM4E (0.58) | HPGDNPC1SMN1; SMN2PPARAPPARG | |
| SCHEMBL13433361 | 0.81 | PPARA (0.59) | PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |