Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 14/20 | 0.51 |
| ▸ | LCK | P06239 | 10/20 | 0.50 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13462163 | 0.80 | TNK2 (0.60) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL3572027 | 0.76 | TNK2 (0.60) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL3566031 | 0.76 | TNK2 (0.55) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL3568276 | 0.76 | TNK2 (0.57) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL13436281 | 0.75 | TNK2 (0.54) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL2973750 | 0.74 | TNK2 (0.65) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL3568744 | 0.74 | TNK2 (0.65) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL13462162 | 0.73 | TNK2 (0.57) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL3566365 | 0.73 | TNK2 (0.58) | TNK2LCKKDRJAK3KMT2A | |
| SCHEMBL3567893 | 0.73 | TNK2 (0.63) | TNK2LCKKDRJAK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674907-B2 | Furanopyridine derivatives and methods of use | AMGEN INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-7674907-B2 | Furanopyridine derivatives and methods of use | AMGEN INC. (US) | 2010-03-09 | — | — | US | disclosed |