Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342841 | 0.94 | MAPT (0.32) | MAPTGCKKDM4EPOLBMEN1 | |
| SCHEMBL1341249 | 0.93 | GCK (0.33) | MAPTGCKALDH1A1KDM4ELMNA | |
| SCHEMBL1342731 | 0.85 | MAPT (0.37) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL1343073 | 0.85 | GCK (0.39) | MAPTGCKALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1343678 | 0.83 | MAPT (0.35) | MAPTGCKCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1343045 | 0.80 | MAPT (0.34) | MAPTGCKLMNAMEN1KMT2A | |
| SCHEMBL1341674 | 0.80 | GCK (0.42) | MAPTGCKALDH1A1KDM4EPOLB | |
| SCHEMBL1342282 | 0.80 | GAA (0.36) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL1341018 | 0.80 | GCK (0.41) | MAPTGCKALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1342879 | 0.80 | NPC1 (0.36) | MAPTGCKALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |
| US-7897628-B2 | {2-[3-(4-Methyl-2-[2-methypropoxy]phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-03-01 | — | — | US | disclosed |