Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697382 | 0.90 | TP53 (0.47) | TP53GAAAURKAKMT2ASMN1; SMN2 | |
| SCHEMBL1342960 | 0.90 | TP53 (0.47) | TP53GAAAURKAKMT2APOLB | |
| SCHEMBL6700223 | 0.90 | TP53 (0.44) | TP53GAAAURKAKMT2APOLB | |
| SCHEMBL1343039 | 0.89 | TP53 (0.46) | TP53GAAAURKAKMT2ASMN1; SMN2 | |
| SCHEMBL6701832 | 0.89 | TP53 (0.48) | TP53GAAAURKAKMT2APOLB | |
| SCHEMBL1343466 | 0.88 | TP53 (0.45) | TP53GAAAURKAKMT2ASMN1; SMN2 | |
| SCHEMBL1343107 | 0.87 | TP53 (0.49) | TP53GAAAURKAKMT2APOLB | |
| SCHEMBL1343075 | 0.86 | TP53 (0.53) | TP53GAAAURKAKMT2APOLB | |
| SCHEMBL6702451 | 0.85 | TP53 (0.46) | TP53GAAAURKAKMT2ASMN1; SMN2 | |
| SCHEMBL1343194 | 0.85 | TP53 (0.52) | TP53GAAKMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |
| US-7897628-B2 | {2-[3-(4-Methyl-2-[2-methypropoxy]phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-03-01 | — | — | US | disclosed |
| US-7384967-B2 | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK A/S (DK) | 2008-06-10 | — | — | US | disclosed |