Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29843895 | 0.90 | TTR (0.48) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL13545555 | 0.86 | TTR (0.47) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL30235603 | 0.85 | ESR1 (0.57) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL4514544 | 0.85 | ESR1 (0.57) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL8375818 | 0.85 | POLB (0.56) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL8375820 | 0.85 | POLB (0.56) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL4514546 | 0.85 | ESR1 (0.57) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL13678677 | 0.85 | ESR1 (0.57) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL30637013 | 0.85 | TTR (0.49) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL11821125 | 0.85 | TTR (0.49) | TTRDPP4CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250250230-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-08-07 | — | — | US | disclosed |
| EP-4508027-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2025-02-19 | — | — | EP | disclosed |
| WO-2023199091-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-10-19 | — | — | WO | disclosed |
| US-7671059-B2 | 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones | NOVARTIS AG (CH) | 2010-03-02 | — | — | US | disclosed |
| US-7671059-B2 | 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones | NOVARTIS AG (CH) | 2010-03-02 | — | — | US | disclosed |
| US-20100004237-A1 | 2-Amino-7,8-dihydro-6H-pyrido[4,3-D]pyrimidin-5-ones | MACHAKEWSKI TIMOTHY D | 2010-01-07 | — | — | US | disclosed |
| US-20100004237-A1 | 2-Amino-7,8-dihydro-6H-pyrido[4,3-D]pyrimidin-5-ones | MACHAKEWSKI TIMOTHY D | 2010-01-07 | — | — | US | disclosed |
| US-20070123546-A1 | 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones | CHIRON CORPORATION | 2007-05-31 | — | — | US | disclosed |
| US-20070123546-A1 | 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones | CHIRON CORPORATION | 2007-05-31 | — | — | US | disclosed |
| WO-2007041362-A1 | 2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D] PYRIMIDIN-5-ONES | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250250230-A1 | HETEROCYCLIC COMPOUND | HCRTR2, HCRTR1, NPY2R | TTR 4869/4885DPP4 3091/4885CA12 3408/4885 |
| US-20070123546-A1 | 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-ones | TYMP, TPMT, TYMS | TTR 11/4885DPP4 63/4885CA12 4630/4885 |
| US-20100004237-A1 | 2-Amino-7,8-dihydro-6H-pyrido[4,3-D]pyrimidin-5-ones | TYMP, TPMT, TYMS | TTR 11/4885DPP4 63/4885CA12 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.