Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535440 | 0.91 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL12593483 | 0.83 | BACE1 (0.39) | BACE1CTSDAPPBACE2 | |
| SCHEMBL8290077 | 0.82 | BACE1 (0.36) | BACE1CTSD | |
| SCHEMBL7514063 | 0.82 | BACE1 (0.38) | BACE1CTSDAPPBACE2 | |
| SCHEMBL12593424 | 0.82 | BACE1 (0.38) | BACE1CTSDAPPBACE2 | |
| SCHEMBL7520191 | 0.82 | BACE1 (0.40) | BACE1CTSDAPPBACE2 | |
| SCHEMBL7513893 | 0.82 | BACE1 (0.38) | BACE1CTSDAPPBACE2 | |
| SCHEMBL17568813 | 0.82 | BACE1 (0.38) | BACE1CTSDAPPBACE2 | |
| SCHEMBL17551649 | 0.82 | BACE1 (0.36) | BACE1CTSD | |
| SCHEMBL7532919 | 0.81 | BACE1 (0.36) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700603-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2010-04-20 | — | — | US | disclosed |
| US-7592348-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |