Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342127 | 0.87 | TP53 (0.56) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1343580 | 0.86 | TP53 (0.45) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1343141 | 0.85 | GAA (0.55) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1343063 | 0.84 | TP53 (0.52) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1343130 | 0.84 | TP53 (0.50) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1342608 | 0.83 | TP53 (0.52) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1343194 | 0.83 | TP53 (0.52) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1341691 | 0.82 | TP53 (0.44) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1342657 | 0.82 | TP53 (0.51) | TP53GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1343843 | 0.81 | TP53 (0.47) | TP53GAARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |
| US-7897628-B2 | {2-[3-(4-Methyl-2-[2-methypropoxy]phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-03-01 | — | — | US | disclosed |