Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13443145 | 0.92 | CYP19A1 (0.48) | CYP19A1CYP26A1CYP17A1CYP3A4 | |
| SCHEMBL13442905 | 0.79 | CYP17A1 (0.37) | CYP17A1KMT2A | |
| SCHEMBL13443144 | 0.77 | CYP19A1 (0.47) | CYP19A1CYP26A1CYP17A1MEN1NR1I2 | |
| SCHEMBL13442919 | 0.75 | CYP11B1 (0.43) | CYP19A1CYP26A1CYP17A1MEN1NR1I2 | |
| SCHEMBL13442923 | 0.72 | CYP19A1 (0.48) | CYP19A1CYP26A1CYP17A1MEN1NR1I2 | |
| SCHEMBL13443147 | 0.71 | CYP11B1 (0.42) | CYP19A1CYP26A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL13442907 | 0.70 | CYP19A1 (0.50) | CYP19A1CYP26A1CYP3A4 | |
| SCHEMBL3389892 | 0.69 | CYP19A1 (0.49) | CYP19A1CYP26A1CYP17A1MEN1NR1I2 | |
| SCHEMBL13442922 | 0.67 | CYP19A1 (0.37) | CYP19A1CYP26A1CYP3A4 | |
| SCHEMBL3394245 | 0.67 | CYP19A1 (0.58) | CYP19A1CYP26A1CYP17A1MEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087478-A1 | HIF-1 Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-08 | — | — | US | disclosed |
| US-7652033-B2 | HIF-1 inhibitors | EMORY UNIVERSITY (US) | 2010-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087478-A1 | HIF-1 Inhibitors | HIF1AN, HIF1A, EGLN2 | CYP19A1 1742/4885CYP26A1 1897/4885CYP17A1 2390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.