Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.66 |
| ▸ | PTK6 | Q13882 | 11/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.47 |
| ▸ | LCK | P06239 | 6/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12443302 | 0.91 | MAPKAPK5 (0.67) | MAPKAPK5PTK6AURKBLCKROCK2 | |
| SCHEMBL1476426 | 0.90 | MAPKAPK5 (0.80) | MAPKAPK5PTK6AURKBLCK | |
| SCHEMBL12443304 | 0.90 | MAPKAPK5 (0.65) | MAPKAPK5PTK6AURKBLCK | |
| SCHEMBL2219234 | 0.88 | MAPKAPK5 (0.83) | MAPKAPK5PTK6AURKBLCKROCK2 | |
| SCHEMBL14368592 | 0.87 | MAPKAPK5 (0.63) | MAPKAPK5PTK6AURKBLCKROCK2 | |
| SCHEMBL1475895 | 0.87 | MAPKAPK5 (0.61) | MAPKAPK5PTK6AURKBLCKKCNH2 | |
| SCHEMBL1476474 | 0.87 | MAPKAPK5 (0.61) | MAPKAPK5PTK6AURKBLCK | |
| SCHEMBL1477845 | 0.85 | MAPKAPK5 (0.59) | MAPKAPK5PTK6AURKBLCKROCK2 | |
| SCHEMBL1475806 | 0.85 | MAPKAPK5 (0.59) | MAPKAPK5PTK6AURKBLCK | |
| SCHEMBL14387555 | 0.83 | MAPKAPK5 (0.65) | MAPKAPK5PTK6AURKBLCKROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | disclosed |
| WO-2007138072-A2 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2007-12-06 | — | — | WO | disclosed |