Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TK1 | P04183 | 2/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057148 | 0.90 | POLB (0.61) | POLBTK1ABCG2ABCB1 | |
| SCHEMBL6129437 | 0.90 | POLB (0.61) | POLBTK1ABCG2ABCB1 | |
| SCHEMBL263767 | 0.88 | POLB (0.64) | POLBTK1 | |
| SCHEMBL3694340 | 0.88 | POLB (0.64) | POLBTK1 | |
| SCHEMBL263768 | 0.88 | POLB (0.64) | POLBTK1 | |
| SCHEMBL15216188 | 0.88 | POLB (0.64) | POLBTK1 | |
| SCHEMBL2985311 | 0.88 | ABCG2 (0.61) | POLBTK1ABCG2ABCB1 | |
| SCHEMBL5179276 | 0.88 | ABCG2 (0.61) | POLBTK1ABCG2ABCB1 | |
| SCHEMBL5367832 | 0.87 | ABCG2 (0.65) | POLBTK1ABCG2ABCB1 | |
| SCHEMBL12907029 | 0.87 | POLB (0.58) | POLBTK1ABCG2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028190-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF USING SAME FOR MODULATING URIC ACID LEVELS | ARDEA BIOSCIENCES, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009070740-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES INC. (US) | 2009-06-04 | — | — | WO | disclosed |