Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.40 |
| ▸ | BCL2 | P10415 | 4/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 12/20 | 0.38 |
| ▸ | LDHA | P00338 | 5/20 | 0.38 |
| ▸ | LDHB | P07195 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2622257 | 0.96 | ALB (0.41) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL13446157 | 0.67 | ALB (0.47) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL2622252 | 0.62 | AKR1B1 (0.64) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL2622255 | 0.62 | ALB (0.51) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL685378 | 0.60 | MCL1 (0.89) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL2622247 | 0.59 | ALB (0.63) | MCL1BCL2ALBAKR1B1LDHA | |
| Gossypol SCHEMBL6661301 | 0.58 | MCL1 (0.79) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL2622254 | 0.58 | AKR1B1 (0.46) | MCL1BCL2ALBAKR1B1LDHA | |
| Gossypol SCHEMBL28826838 | 0.58 | MCL1 (0.92) | MCL1BCL2ALBAKR1B1LDHA | |
| SCHEMBL20243430 | 0.58 | MCL1 (0.90) | MCL1BCL2ALBAKR1B1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069344-A1 | SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS | BCL2L1, BCL2, BCL2L11 | MCL1 45/4885BCL2 2/4885ALB 4693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.