Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16225017 | 1.00 | TSHR (0.52) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL1784819 | 0.88 | TSHR (0.47) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL30472836 | 0.87 | TSHR (0.53) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL29580263 | 0.86 | TSHR (0.52) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL29016097 | 0.86 | TSHR (0.52) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL14690420 | 0.86 | TSHR (0.52) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL569009 | 0.86 | TSHR (0.52) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL10239104 | 0.85 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL13700339 | 0.85 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL29311500 | 0.85 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033240-A2 | CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF | NEKTAR THERAPEUTICS (US) | 2010-03-25 | — | — | WO | disclosed |