Sorivudine

Sorivudine

SCHEMBL13447883

O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)C(O)C2O)cc1/C=C/Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TK2 O00142 7/20 1.00
PYGM P11217 3/20 0.67
TK1 P04183 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
TSHR P16473 1/20 0.65
BLM P54132 1/20 0.65
PMP22 Q01453 1/20 0.65
NPSR1 Q6W5P4 1/20 0.65
P2RY2 P41231 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sorivudine SCHEMBL4658822 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL16555082 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL1981707 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL3503357 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL82640 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL16555084 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL13413053 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL4292930 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL3503360 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4
Sorivudine SCHEMBL5511785 1.00 TK2 (1.00) TK2PYGMTK1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117731769-A Nucleic acid vaccine for Varicella Zoster Virus (VZV) 摩登纳特斯有限公司 2024-03-22 CN disclosed
EP-4301405-A1 VLP ENTEROVIRAL VACCINES ModernaTX, Inc. (US) 2024-01-10 EP disclosed
CN-117222422-A Sanopassing polypeptides and their use in the treatment of cancer 旗舰创业创新五公司 2023-12-12 CN disclosed
CN-116726203-A Combination of MRNA encoding immunomodulatory polypeptides and uses thereof 莫得纳特斯公司 2023-09-12 CN disclosed
CN-109476718-B Combination of MRNA encoding immunomodulatory polypeptides and uses thereof 莫得纳特斯公司 2023-07-04 CN disclosed
CN-115837014-A Polynucleotides encoding relaxin 摩登纳特斯有限公司 2023-03-24 CN disclosed
CN-109640962-B Polynucleotides encoding relaxin 摩登纳特斯有限公司 2022-07-19 CN disclosed
CN-114404581-A Cancer vaccine 摩登纳特斯有限公司 2022-04-29 CN disclosed
CN-108430456-B Cancer vaccine 摩登纳特斯有限公司 2022-01-18 CN disclosed
CN-112996854-A High purity PEG lipids and uses thereof 摩登纳特斯有限公司 2021-06-18 CN disclosed
CN-105566304-B Sulfur-bearing uridine anticancer compound and its intermediate and preparation method 大连大学 2019-04-30 CN disclosed
CN-105566304-A Sulfur-containing uridine anticancer compound and intermediate and preparation method thereof UNIV DALIAN 2016-05-11 CN disclosed
US-9334300-B2 Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates MBC PHARMA, INC. (US) 2016-05-10 US disclosed
US-7674778-B2 Oligonucleotides comprising a conjugate group linked through a C5-modified pyrimidine ALNYLAM PHARMACEUTICALS (US) 2010-03-09 US disclosed