SCHEMBL1344985

SCHEMBL1344985

CCCCCCCCN[SiH](C)C

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 8/20 0.50
TSHR P16473 2/20 0.48
ALDH1A1 P00352 1/20 0.48
THRB P10828 1/20 0.44
ADH1B P00325 1/20 0.44
ADH1C P00326 1/20 0.44
ADH1A P07327 1/20 0.44
ADH4 P08319 1/20 0.44
ADH7 P40394 1/20 0.44
PPARA Q07869 2/20 0.39
GBA1 P04062 4/20 0.38
CASP2 P42575 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27743053 1.00 EPHX1 (0.50) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL28919391 1.00 EPHX1 (0.50) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL27722565 1.00 EPHX1 (0.50) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL10708514 1.00 EPHX1 (0.50) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL10879634 1.00 EPHX1 (0.50) EPHX1TSHRALDH1A1THRBADH1B
Bromide SCHEMBL29250980 0.97 EPHX1 (0.48) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL10630592 0.80 EPHX1 (0.52) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL28446156 0.80 EPHX1 (0.52) EPHX1TSHRALDH1A1THRBADH1B
SCHEMBL10878118 0.78 TSHR (0.48) EPHX1TSHRALDH1A1THRBADH1B
Decane SCHEMBL29169441 0.71 TSHR (0.73) TSHRALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2145929-B1 Method for manufacturing redispersible, surface-modified silicon dioxide particles EVONIK OPERATIONS GMBH (DE) 2020-06-24 EP disclosed
EP-2145928-B1 Dispersion made of hydrophobic silicon dioxide particles and granulate made from same EVONIK DEGUSSA GMBH (DE) 2017-09-13 EP disclosed
EP-1807347-B1 METHOD OF PREPARING HYDROPHOBIC SILICA DIRECTLY FROM AN AQUEOUS COLLOIDAL SILICA DISPERSION CABOT CORP (US) 2014-01-22 EP disclosed
US-8399093-B2 Process for preparing redispersible surface-modified silicon dioxide particles EVONIK DEGUSSA GMBH (DE) 2013-03-19 US disclosed
EP-2480500-A1 PROCESS FOR SURFACE MODIFICATION OF METAL OXIDE PARTICLES Evonik Degussa GmbH (DE) 2012-08-01 EP disclosed
US-8062820-B2 Toner composition and method of preparing same CABOT CORPORATION (US) 2011-11-22 US disclosed
US-20110123806-A1 DISPERSION OF HYDROPHOBICIZED SILICON DIOXIDE PARTICLES AND GRANULES THEREOF EVONIK DEGUSSA GMBH (DE) 2011-05-26 US disclosed
US-20110086958-A1 PROCESS FOR PREPARING REDISPERSIBLE SURFACE-MODIFIED SILICON DIOXIDE PARTICLES EVONIK DEGUSSA GMBH (DE) 2011-04-14 US disclosed
WO-2011032814-A1 PROCESS FOR SURFACE MODIFICATION OF METAL OXIDE PARTICLES EVONIK DEGUSSA GMBH (DE) 2011-03-24 WO disclosed
US-7811540-B2 silylamine treating agent; reacting the surface silanol groups to effectively replace the hydrophilic silanol groups with hydrophobic chemical group; toners CABOT CORPORATION (US) 2010-10-12 US disclosed
WO-2010006839-A2 DISPERSION OF HYDROPHOBICIZED SILICON DIOXIDE PARTICLES AND GRANULES THEREOF EVONIK DEGUSSA GMBH (DE) 2010-01-21 WO disclosed
WO-2010006837-A2 PROCESS FOR PREPARING REDISPERSIBLE SURFACE-MODIFIED SILICON DIOXIDE PARTICLES EVONIK DEGUSSA GMBH (DE) 2010-01-21 WO disclosed
EP-2145928-A1 Dispersion made of hydrophobic silicon dioxide particles and granulate made from same Evonik Degussa GmbH (DE) 2010-01-20 EP disclosed
EP-2145929-A1 Method for manufacturing redispersible, surface-modified silicon dioxide particles Evonik Degussa GmbH (DE) 2010-01-20 EP disclosed
WO-2007133669-A2 TONER COMPOSITION AND METHOD OF PREPARING SAME CABOT CORPORATION (US) 2007-11-22 WO disclosed
US-20070264502-A1 Toner composition and method of preparing same CABOT CORPORATION (US) 2007-11-15 US disclosed
EP-1807347-A2 METHOD OF PREPARING HYDROPHOBIC SILICA DIRECTLY FROM AN AQUEOUS COLLOIDAL SILICA DISPERSION CABOT CORPORATION (US) 2007-07-18 EP disclosed
US-20060171872-A1 silylamine treating agent; reacting the surface silanol groups to effectively replace the hydrophilic silanol groups with hydrophobic chemical group; toners CABOT CORPORATION (US) 2006-08-03 US disclosed
WO-2006045012-A2 METHOD OF PREPARING HYDROPHOBIC SILICA DIRECTLY FROM AN AQUEOUS COLLOIDAL SILICA DISPERSION CABOT CORPORATION (US) 2006-04-27 WO disclosed