Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 10/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690147 | 0.91 | SCARB1 (0.54) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL1302167 | 0.91 | SCARB1 (0.46) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL13986437 | 0.91 | SCARB1 (0.48) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL13986432 | 0.90 | MAPK14 (0.49) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL13986438 | 0.89 | MAPK14 (0.46) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL13986452 | 0.89 | MAPK14 (0.47) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL690505 | 0.89 | MAPK14 (0.44) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL689701 | 0.88 | SCARB1 (0.45) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL12103083 | 0.87 | MAPK14 (0.46) | SCARB1MAPK14LYNMAPK9BRAF | |
| SCHEMBL689711 | 0.87 | MAPK14 (0.45) | SCARB1MAPK14LYNMAPK9BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786801-B1 | 2-ARYLCARBAMOYL-INDOLES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-03-10 | — | — | EP | disclosed |
| US-7470692-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470692-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-30 | — | — | US | disclosed |