Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | TOP2A | P11388 | 3/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 9/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345435 | 0.78 | TOP2A (0.42) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL2570886 | 0.78 | TOP2A (0.42) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL1345437 | 0.78 | TOP2A (0.42) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL2570884 | 0.78 | TOP2A (0.42) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL1344390 | 0.77 | CNR1 (0.45) | TOP2ATOP2BKMT2ATOP1POLB | |
| SCHEMBL2194453 | 0.76 | TOP2A (0.56) | TOP2ATOP2BGSK3BKMT2APOLB | |
| SCHEMBL1345049 | 0.74 | GSK3B (0.42) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL1184931 | 0.72 | GSK3B (0.37) | PIM1GSK3B | |
| SCHEMBL1344895 | 0.71 | STAT3 (0.40) | TOP2ATOP2BGSK3BMEN1KMT2A | |
| SCHEMBL1342568 | 0.71 | STAT3 (0.40) | TOP2ATOP2BGSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063221-B2 | Aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-11-22 | — | — | US | disclosed |
| EP-2383271-A1 | Aminoquinolones as GSK-3 Inhibitors | Kyorin Pharmaceutical Co., Ltd. (JP) | 2011-11-02 | — | — | EP | disclosed |