Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.79 |
| ▸ | PIM3 | Q86V86 | 20/20 | 0.79 |
| ▸ | PIM2 | Q9P1W9 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13458491 | 1.00 | PIM1 (0.79) | PIM1PIM3PIM2 | |
| SCHEMBL3219178 | 0.89 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL9608822 | 0.89 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL3216816 | 0.89 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL14235351 | 0.87 | PIM1 (0.89) | PIM1PIM3PIM2 | |
| SCHEMBL17115578 | 0.86 | PIM1 (0.90) | PIM1PIM3PIM2 | |
| SCHEMBL15613762 | 0.86 | PIM1 (0.90) | PIM1PIM3PIM2 | |
| SCHEMBL13458375 | 0.86 | PIM3 (0.80) | PIM1PIM3PIM2 | |
| SCHEMBL13458218 | 0.86 | PIM3 (0.80) | PIM1PIM3PIM2 | |
| SCHEMBL9608653 | 0.84 | PIM1 (1.00) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344474-B1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| WO-2010026124-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |