Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 18/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL568107 | 0.84 | CCR1 (0.69) | CCR1KCNH2ADRB1CYP3A4 | |
| SCHEMBL567793 | 0.77 | CCR1 (0.72) | CCR1KCNH2 | |
| SCHEMBL567943 | 0.76 | CCR1 (0.71) | CCR1KCNH2CYP3A4 | |
| SCHEMBL568127 | 0.75 | CCR1 (0.66) | CCR1KCNH2SMO | |
| SCHEMBL8509503 | 0.74 | CCR1 (0.46) | CCR1KCNH2SMOADRB1CYP3A4 | |
| SCHEMBL568128 | 0.73 | CCR1 (0.47) | CCR1KCNH2ADRB1 | |
| SCHEMBL568021 | 0.72 | CCR1 (0.66) | CCR1KCNH2 | |
| SCHEMBL567819 | 0.71 | CCR1 (1.00) | CCR1KCNH2 | |
| SCHEMBL567318 | 0.70 | CCR1 (0.77) | CCR1KCNH2 | |
| SCHEMBL1135716 | 0.70 | CCR1 (0.75) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063065-B2 | Azaindazole compounds as CCR1 receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-22 | — | — | US | disclosed |