SCHEMBL13460950

SCHEMBL13460950

O=C1c2ccc(C(c3ccc4c(c3)C(=O)N(c3ccccc3)C4=O)(C(F)(F)F)C(F)(F)F)cc2C(=O)N1c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.55
CA9 Q16790 4/20 0.49
CA12 O43570 4/20 0.49
CA1 P00915 3/20 0.49
CA2 P00918 2/20 0.45
ESR2 Q92731 1/20 0.42
ALDH1A1 P00352 2/20 0.42
NR1H3 Q13133 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
GFER P55789 1/20 0.42
SCN2A Q99250 1/20 0.41
CA7 P43166 1/20 0.41
HSPA1A P0DMV8 1/20 0.41
PABPC1 P11940 1/20 0.41
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29906097 1.00 ESR1 (0.55) ESR1CA9CA12CA1CA2
SCHEMBL24380215 0.93 ESR1 (0.49) ESR1CA9CA12CA1CA2
SCHEMBL17281687 0.88 BRD4 (0.52) ESR1CA9CA12CA1CA2
SCHEMBL24077133 0.87 ESR1 (0.58) ESR1CA9CA12CA1CA2
SCHEMBL22580660 0.86 ESR1 (0.42) ESR1CA9CA12CA1ALDH1A1
SCHEMBL13461010 0.85 BRD4 (0.52) ESR1CA9CA12CA1ALDH1A1
SCHEMBL13461076 0.85 BRD4 (0.52) ESR1CA9CA12CA1ALDH1A1
SCHEMBL25969208 0.85 ESR1 (0.64) ESR1CA9CA12CA1CA2
SCHEMBL13819250 0.85 CA9 (0.47) ESR1CA9CA12CA1CA2
SCHEMBL25161435 0.84 CA9 (0.71) CA9CA12CA1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2159222-A1 Additives to improve the electret behaviour of polycarbonates Bayer MaterialScience AG (DE) 2010-03-03 EP disclosed