Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.69 |
| ▸ | JAK3 | P52333 | 3/20 | 0.69 |
| ▸ | IKBKB | O14920 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512584 | 0.87 | JAK2 (0.67) | JAK2JAK3IKBKB | |
| SCHEMBL3510590 | 0.87 | JAK2 (0.67) | JAK2JAK3IKBKB | |
| SCHEMBL3512260 | 0.84 | JAK2 (0.64) | JAK2JAK3IKBKB | |
| SCHEMBL3509407 | 0.84 | JAK2 (0.64) | JAK2JAK3IKBKB | |
| SCHEMBL3512122 | 0.81 | JAK2 (1.00) | JAK2JAK3IKBKB | |
| SCHEMBL13464856 | 0.79 | JAK2 (0.77) | JAK2JAK3IKBKB | |
| SCHEMBL1579949 | 0.78 | JAK2 (1.00) | JAK2JAK3IKBKB | |
| SCHEMBL1890249 | 0.78 | JAK2 (1.00) | JAK2JAK3IKBKB | |
| SCHEMBL1579845 | 0.77 | JAK2 (1.00) | JAK2JAK3IKBKB | |
| SCHEMBL14011075 | 0.76 | JAK2 (0.77) | JAK2JAK3IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |