Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.69 |
| ▸ | EED | O75530 | 1/20 | 0.64 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.64 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.64 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.64 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710916 | 0.92 | EZH2 (0.77) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL15709792 | 0.92 | EZH2 (0.77) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL17804383 | 0.92 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL15710369 | 0.91 | EZH2 (0.77) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL15700506 | 0.90 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL17148707 | 0.90 | EZH2 (0.65) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18830035 | 0.90 | EZH2 (0.66) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13280128 | 0.90 | EZH2 (0.69) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18829868 | 0.88 | EZH2 (0.75) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13468071 | 0.88 | EZH2 (0.75) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725314-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2012142513-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2012-10-18 | — | — | WO | disclosed |