Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | DUT | P33316 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19303349 | 0.86 | POLB (0.52) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL23710654 | 0.86 | POLB (0.52) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL13471838 | 0.86 | POLB (0.52) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL19223339 | 0.83 | POLB (0.45) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL19204593 | 0.82 | POLB (0.44) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL19223449 | 0.82 | POLB (0.44) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL13471129 | 0.81 | POLB (0.38) | POLBHSD17B10 | |
| SCHEMBL9909470 | 0.81 | POLB (0.43) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL13469459 | 0.80 | POLB (0.42) | POLBHSD17B10PKMDUTCRBN | |
| SCHEMBL13468112 | 0.80 | POLB (0.42) | POLBHSD17B10PKMDUTCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012142085-A1 | 2'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012142075-A1 | 2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-10-18 | — | — | WO | disclosed |