Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.33 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21788646 | 0.86 | HSD17B10 (0.48) | APPSPHK1PLA2G2CHSD17B10PTGS1 | |
| SCHEMBL10036616 | 0.82 | — | — | |
| SCHEMBL11767173 | 0.81 | SPHK1 (0.37) | APPSPHK1PLA2G2CHSD17B10 | |
| SCHEMBL14174098 | 0.80 | TDP1 (0.37) | APP | |
| SCHEMBL12777783 | 0.80 | APP (0.32) | APP | |
| SCHEMBL421993 | 0.79 | APP (0.50) | APPPTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL16265140 | 0.79 | USP2 (0.42) | APPSPHK1PLA2G2CHSD17B10CYP2C19 | |
| SCHEMBL8948718 | 0.78 | USP2 (0.32) | APP | |
| SCHEMBL8150525 | 0.78 | EPHX2 (0.32) | APPPLA2G2C | |
| SCHEMBL6756557 | 0.78 | APP (0.37) | APPPTGS1PDE4ALMNASLC6A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2154183-A1 | Coated substrates and methods for their preparation | Dow Corning Corporation (US) | 2010-02-17 | — | — | EP | disclosed |