Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.36 |
| ▸ | RAB9A | P51151 | 13/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.36 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13477353 | 0.83 | GCK (0.40) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13477350 | 0.82 | GCK (0.47) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13477360 | 0.82 | GCK (0.48) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13477351 | 0.80 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13477358 | 0.80 | GCK (0.51) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13477349 | 0.80 | GCK (0.50) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13477355 | 0.80 | KMT2A (0.38) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12513816 | 0.77 | GCK (0.36) | NPC1RAB9ASMN1; SMN2NFKB1HTT | |
| SCHEMBL2212256 | 0.63 | GCK (0.53) | — | |
| SCHEMBL2213959 | 0.63 | GCK (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8344003-B2 | 2-pyridinecarboxamide derivatives | MSD K. K. (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | NPC1 4261/4885RAB9A 3609/4885SMN1; SMN2 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.