Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.55 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14450771 | 0.91 | CXCR2 (0.53) | CXCR2CXCR1 | |
| SCHEMBL14511220 | 0.87 | CXCR2 (0.72) | CXCR2CXCR1 | |
| SCHEMBL13479470 | 0.85 | CXCR2 (0.68) | CXCR2CXCR1 | |
| SCHEMBL12263148 | 0.83 | CXCR2 (0.78) | CXCR2CXCR1CCR6 | |
| SCHEMBL12263149 | 0.80 | CXCR2 (0.75) | CXCR2CXCR1CCR6 | |
| SCHEMBL14450831 | 0.76 | CXCR2 (0.58) | CXCR2CXCR1 | |
| SCHEMBL14450117 | 0.76 | CXCR2 (0.55) | CXCR2CXCR1 | |
| SCHEMBL14450151 | 0.76 | CXCR2 (0.57) | CXCR2CXCR1 | |
| SCHEMBL12263062 | 0.75 | CXCR2 (0.80) | CXCR2CXCR1 | |
| SCHEMBL12311077 | 0.75 | CXCR2 (0.80) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1818325-B1 | 3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands | SCHERING CORP (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-1818325-A2 | 3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands | SCHERING CORPORATION (US) | 2007-08-15 | — | — | EP | disclosed |