Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 18/20 | 0.75 |
| ▸ | KDR | P35968 | 18/20 | 0.75 |
| ▸ | KIT | P10721 | 11/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | YES1 | P07947 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480248 | 0.99 | PDGFRB (0.73) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL14450418 | 0.95 | PDGFRB (0.80) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3136220 | 0.90 | PDGFRB (0.75) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3136225 | 0.90 | PDGFRB (0.75) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3136212 | 0.90 | PDGFRB (0.75) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3133205 | 0.90 | PDGFRB (0.92) | PDGFRBKDRKITAURKAFGFR1 | |
| SCHEMBL3136234 | 0.90 | PDGFRB (0.75) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3133199 | 0.90 | PDGFRB (0.92) | PDGFRBKDRKITAURKAFGFR1 | |
| SCHEMBL3134399 | 0.89 | PDGFRB (0.73) | PDGFRBKDRKITAURKAAURKB | |
| SCHEMBL3135000 | 0.89 | PDGFRB (0.73) | PDGFRBKDRKITAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157093-A1 | PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-02-24 | — | — | EP | disclosed |