Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12435857 | 0.94 | SPPL2A (0.51) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL12434851 | 0.94 | SPPL2A (0.51) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL8248846 | 0.94 | SPPL2A (0.51) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL12434835 | 0.91 | SPPL2A (0.53) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL8238981 | 0.91 | SPPL2A (0.53) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL4972751 | 0.90 | SPPL2A (0.56) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL12156747 | 0.90 | SPPL2A (0.70) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL12157059 | 0.90 | SPPL2A (0.53) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL30718549 | 0.90 | SPPL2A (0.51) | SPPL2ACYP3A4MLNRABCB11LMNA | |
| SCHEMBL14338904 | 0.90 | SPPL2A (0.70) | SPPL2ACYP3A4MLNRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659404-B2 | Broad spectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2010-02-09 | — | — | US | disclosed |