Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 13/20 | 0.67 |
| ▸ | EGFR | P00533 | 7/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | PRKCG | P05129 | 1/20 | 0.60 |
| ▸ | PRKCB | P05771 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | PRKCH | P24723 | 1/20 | 0.60 |
| ▸ | PRKCI | P41743 | 1/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480786 | 0.92 | MAP3K8 (0.67) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL13480779 | 0.88 | EGFR (0.59) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL13480745 | 0.86 | EGFR (0.69) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL5608396 | 0.84 | MAP3K8 (0.56) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL13480758 | 0.84 | EGFR (0.53) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL5456072 | 0.83 | EGFR (0.90) | EGFRPRKD3SRCPRKD1MAPK14 | |
| SCHEMBL13480754 | 0.82 | EGFR (0.51) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL5119072 | 0.80 | MAP3K8 (1.00) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL3192981 | 0.79 | EGFR (0.67) | MAP3K8EGFRMAPK13PRKD3PRKCG | |
| SCHEMBL13672653 | 0.77 | EGFR (1.00) | MAP3K8EGFRPRKD3SRCPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |
| US-7659284-B2 | Inhibitors of ATP-protein kinase; 7-(3-chloro-4-fluoro-phenylamino)-2-(4-pyrrolidin-1-ylmethyl-phenylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-09 | — | — | US | disclosed |