Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | MEN1 | O00255 | 9/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | USP2 | O75604 | 7/20 | 0.53 |
| ▸ | GAA | P10253 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | CASP1 | P29466 | 5/20 | 0.53 |
| ▸ | CASP7 | P55210 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203725 | 0.86 | MEN1 (0.56) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13486816 | 0.85 | KMT2A (0.55) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13486814 | 0.84 | MEN1 (0.56) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13486815 | 0.84 | MEN1 (0.59) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13486922 | 0.81 | SLC16A3 (0.65) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3212258 | 0.78 | MEN1 (0.65) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL30057776 | 0.78 | MEN1 (0.65) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3203597 | 0.75 | KMT2A (0.68) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3212045 | 0.75 | MEN1 (0.67) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13486811 | 0.74 | KMT2A (0.57) | ALDH1A1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048604-A1 | Ligands for Aldoketoreductases | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2010-02-25 | — | — | US | disclosed |
| US-20100048604-A1 | Ligands for Aldoketoreductases | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048604-A1 | Ligands for Aldoketoreductases | AKR1C2, AKR1C1, AKR1B1 | ALDH1A1 18/4885MEN1 2261/4885KMT2A 3808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.