Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 3/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 5/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | GPR39 | O43194 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13492744 | 0.90 | ACACB (0.36) | TYRO3MERTKGAS6FLT3ACACB | |
| SCHEMBL10093997 | 0.85 | IRAK4 (0.44) | IRAK4 | |
| SCHEMBL10094123 | 0.82 | EHMT2 (0.31) | TYRO3MERTKGAS6FLT3EHMT2 | |
| SCHEMBL13492761 | 0.82 | PIK3CA (0.39) | TYRO3MERTKGAS6FLT3ACACB | |
| SCHEMBL13492717 | 0.80 | ACACB (0.34) | ACACB | |
| SCHEMBL10093995 | 0.79 | IRAK4 (0.39) | ACACBIRAK4 | |
| SCHEMBL13492707 | 0.77 | MTOR (0.35) | TYRO3MERTKGAS6FLT3ACACB | |
| SCHEMBL10093999 | 0.77 | IRAK4 (0.44) | IRAK4PIK3CAMTOR | |
| SCHEMBL10094224 | 0.75 | PIK3CA (0.35) | ACACBIRAK4PIK3CAMTORSYK | |
| SCHEMBL13492718 | 0.74 | PIK3CA (0.42) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022125-A1 | ETHYNYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2010-02-25 | — | — | WO | disclosed |