Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198328 | 0.94 | FLT3 (0.41) | FLT3HTR2AHTR2CMAPK14EPHX2 | |
| SCHEMBL13495549 | 0.91 | MAPK14 (0.42) | FLT3MAPK14EPHX2 | |
| SCHEMBL3200481 | 0.91 | MAPK14 (0.41) | FLT3HTR2AHTR2CMAPK14RET | |
| SCHEMBL3213052 | 0.88 | MAPK14 (0.42) | FLT3MAPK14 | |
| SCHEMBL3209349 | 0.86 | MAPK14 (0.43) | FLT3HTR2AHTR2CMAPK14RET | |
| SCHEMBL3198158 | 0.85 | MAPK14 (0.43) | FLT3MAPK14EPHX2 | |
| SCHEMBL3218578 | 0.85 | MAPK14 (0.42) | FLT3HTR2AHTR2CMAPK14 | |
| SCHEMBL3208082 | 0.85 | MAPK14 (0.42) | FLT3HTR2AHTR2CMAPK14 | |
| SCHEMBL3206182 | 0.84 | MAPK14 (0.45) | HTR2AHTR2CMAPK14RET | |
| SCHEMBL3212687 | 0.83 | MAPK14 (0.43) | MAPK14RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019930-A1 | UREA DERIVATIVES AS INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | WO | disclosed |