Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3215072 | 0.93 | MAPK14 (0.49) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3210149 | 0.91 | MAPK14 (0.51) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL13487789 | 0.88 | MAPK14 (0.49) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3198172 | 0.87 | MAPK14 (0.51) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3218628 | 0.87 | MAPK14 (0.53) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3222738 | 0.86 | MAPK14 (0.48) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3198272 | 0.86 | MAPK14 (0.51) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL13487649 | 0.86 | MAPK14 (0.46) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3222718 | 0.85 | MAPK14 (0.47) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 | |
| SCHEMBL3221037 | 0.85 | MAPK14 (0.47) | MAPK14RPS6KB1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019930-A1 | UREA DERIVATIVES AS INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | WO | disclosed |