Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.71 |
| ▸ | JAK2 | O60674 | 13/20 | 0.71 |
| ▸ | JAK3 | P52333 | 10/20 | 0.71 |
| ▸ | TYK2 | P29597 | 5/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | MARK3 | P27448 | 2/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.59 |
| ▸ | STK3 | Q13188 | 2/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.59 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.59 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.59 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.59 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20183356 | 0.88 | JAK1 (0.91) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183359 | 0.88 | JAK1 (0.91) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL1846276 | 0.85 | JAK3 (0.78) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183430 | 0.83 | JAK2 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL18581919 | 0.83 | JAK2 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183423 | 0.83 | JAK2 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| Hydrochloric Acid SCHEMBL20183441 | 0.83 | JAK2 (0.98) | JAK1JAK2JAK3TYK2KCNH2 | |
| Hydrochloric Acid SCHEMBL20183449 | 0.83 | JAK2 (0.98) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL352920 | 0.80 | JAK2 (0.68) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183339 | 0.78 | JAK2 (0.89) | JAK1JAK2JAK3TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014930-A2 | THERAPEUTIC AGENTS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2010-02-04 | — | — | WO | disclosed |