Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12395224 | 0.87 | JAK3 (0.52) | JAK3JAK2JAK1TYK2DRD2 | |
| SCHEMBL12395136 | 0.78 | JAK3 (0.53) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12395223 | 0.77 | CHEK2 (0.30) | — | |
| SCHEMBL12395222 | 0.75 | JAK3 (0.54) | JAK3JAK2JAK1TYK2DRD2 | |
| SCHEMBL12395231 | 0.69 | JAK3 (0.60) | JAK3JAK2JAK1TYK2DRD2 | |
| SCHEMBL12395135 | 0.66 | JAK3 (0.56) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL9920437 | 0.64 | JAK2 (0.50) | JAK3JAK2JAK1TYK2DRD2 | |
| SCHEMBL12395138 | 0.63 | MAP4K4 (0.47) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12395344 | 0.62 | JAK3 (0.50) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12395117 | 0.60 | JAK3 (0.63) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014930-A2 | THERAPEUTIC AGENTS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2010-02-04 | — | — | WO | disclosed |