Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.70 |
| ▸ | ITK | Q08881 | 7/20 | 0.70 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 8/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13166579 | 0.88 | EGFR (0.75) | EGFRITKBTKSYKCDK4 | |
| SCHEMBL13498264 | 0.86 | EGFR (0.70) | EGFRITKBTKSYK | |
| SCHEMBL12519661 | 0.83 | EGFR (1.00) | EGFRITKBTK | |
| SCHEMBL656179 | 0.75 | SYK (0.69) | EGFRITKBTKSYKCDK4 | |
| SCHEMBL20927131 | 0.74 | EGFR (0.63) | EGFRITKBTKSYK | |
| SCHEMBL12519767 | 0.74 | EGFR (0.75) | EGFRITKBTKSYK | |
| SCHEMBL21443478 | 0.74 | EGFR (0.75) | EGFRITKBTKSYK | |
| SCHEMBL12519793 | 0.73 | EGFR (0.83) | EGFRITK | |
| SCHEMBL20927092 | 0.71 | EGFR (0.59) | EGFRITKBTKSYKCDK4 | |
| SCHEMBL2357718 | 0.70 | EGFR (0.69) | EGFRITKBTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029610-A1 | Heteroaryl Compounds and Uses Thereof | AVILA THERAPEUTICS, INC. (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029610-A1 | Heteroaryl Compounds and Uses Thereof | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ITK 2697/4885BTK 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.