Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.68 |
| ▸ | CHAT | P28329 | 1/20 | 0.68 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29382721 | 0.82 | SNCA (1.00) | SNCACHATTTRFABP4CCNA2 | |
| SCHEMBL30261938 | 0.82 | SNCA (1.00) | SNCACHATTTRFABP4CCNA2 | |
| SCHEMBL64271 | 0.82 | SNCA (1.00) | SNCACHATTTRFABP4CCNA2 | |
| Potassium SCHEMBL1082234 | 0.81 | SNCA (0.97) | SNCACHATTTRFABP4CCNA2 | |
| SCHEMBL20574382 | 0.81 | SNCA (0.97) | SNCACHATTTRFABP4CCNA2 | |
| Pyrophosphoric Acid SCHEMBL31296093 | 0.76 | SNCA (0.81) | SNCACHATTTRFABP4CCNA2 | |
| SCHEMBL11508403 | 0.71 | SNCA (0.75) | SNCACHATTTRFABP4CCNA2 | |
| SCHEMBL30449729 | 0.71 | SNCA (0.75) | SNCACHATTTRFABP4CCNA2 | |
| SCHEMBL12177963 | 0.71 | SNCA (0.75) | SNCACHATTTRFABP4CCNA2 | |
| Potassium Ion SCHEMBL1082232 | 0.69 | SNCA (0.72) | SNCACHATTTRFABP4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404805-B2 | Characterization of GRP94-ligand interactions and purification, screening, and therapeutic methods relating thereto | DUKE UNIVERSITY (US) | 2013-03-26 | — | — | US | disclosed |
| US-20100028905-A1 | CHARACTERIZATION OF GRP94-LIGAND INTERACTIONS AND PURIFICATION, SCREENING, AND THERAPEUTIC METHODS RELATING THERETO | DUKE UNIVERSITY (US) | 2010-02-04 | — | — | US | disclosed |