Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13501663 | 0.86 | F2RL1 (0.39) | F2RL1ENPP2HDAC2HDAC1GRIA1 | |
| SCHEMBL908219 | 0.80 | ABCB1 (0.48) | F2RL1HDAC2HDAC1 | |
| SCHEMBL908218 | 0.80 | ABCB1 (0.48) | F2RL1HDAC2HDAC1 | |
| SCHEMBL25458542 | 0.77 | MEN1 (0.50) | HTTSUV39H2MEN1TSHRKMT2A | |
| SCHEMBL25458611 | 0.76 | CKS1B (0.48) | SUV39H2MEN1KMT2A | |
| SCHEMBL25460214 | 0.76 | MAPT (0.47) | SUV39H2HPGD | |
| SCHEMBL907656 | 0.75 | CKS1B (0.45) | GRIA1NR1H2SUV39H2MEN1KMT2A | |
| SCHEMBL18031540 | 0.73 | SCN9A (0.56) | F2RL1ENPP2GRIA1HTTSUV39H2 | |
| SCHEMBL17298980 | 0.72 | F2RL1 (0.45) | F2RL1ENPP2GRIA1 | |
| SCHEMBL16711314 | 0.72 | GRM5 (0.50) | F2RL1HTTNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662830-B2 | Substituted biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2010-02-16 | — | — | US | disclosed |