Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.52 |
| ▸ | BRAF | P15056 | 15/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891464 | 0.91 | BRAF (0.57) | RAF1BRAFLCK | |
| SCHEMBL2892279 | 0.86 | BRAF (0.57) | RAF1BRAFLCK | |
| SCHEMBL2895398 | 0.83 | RAF1 (0.58) | RAF1BRAFLCK | |
| SCHEMBL2894193 | 0.81 | BRAF (0.54) | RAF1BRAFLCK | |
| SCHEMBL2895104 | 0.81 | RAF1 (0.57) | RAF1BRAFLCK | |
| SCHEMBL2891664 | 0.79 | RAF1 (0.61) | RAF1BRAFLCK | |
| SCHEMBL2893405 | 0.78 | BRAF (0.67) | RAF1BRAFLCK | |
| SCHEMBL2886836 | 0.76 | RAF1 (0.57) | RAF1BRAFLCK | |
| SCHEMBL2892768 | 0.75 | BRAF (0.62) | RAF1BRAFLCK | |
| SCHEMBL2891778 | 0.75 | BRAF (0.67) | RAF1BRAFLCKP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299108-B2 | for treatment of hematological/hormone-dependent cancer | NOVARTIS AG (CH) | 2012-10-30 | — | — | US | disclosed |