Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.56 |
| ▸ | RAF1 | P04049 | 11/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | PAK3 | O75914 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891679 | 0.91 | BRAF (0.57) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2891678 | 0.91 | BRAF (0.68) | BRAFRAF1KDR | |
| SCHEMBL2897957 | 0.91 | BRAF (0.56) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2886099 | 0.91 | RAF1 (0.56) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2892354 | 0.91 | BRAF (0.56) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2897888 | 0.89 | BRAF (0.52) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2889367 | 0.89 | BRAF (0.65) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2890938 | 0.89 | BRAF (0.65) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2891234 | 0.88 | BRAF (0.54) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2891799 | 0.88 | BRAF (0.58) | BRAFRAF1KDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299108-B2 | for treatment of hematological/hormone-dependent cancer | NOVARTIS AG (CH) | 2012-10-30 | — | — | US | disclosed |