Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13504459 | 1.00 | JAK2 (0.51) | JAK2JAK3PTK2BTKUSP30 | |
| SCHEMBL3305295 | 0.89 | JAK2 (0.46) | JAK2JAK3PTK2BTKUSP30 | |
| SCHEMBL3305298 | 0.89 | JAK2 (0.46) | JAK2JAK3PTK2BTKUSP30 | |
| SCHEMBL3297909 | 0.88 | EGLN2 (0.42) | JAK2JAK3PTK2EGLN2JAK1 | |
| SCHEMBL3309857 | 0.87 | JAK2 (0.46) | JAK2JAK3PTK2BTKPARP1 | |
| SCHEMBL13504477 | 0.83 | JAK2 (0.44) | JAK2JAK3PTK2EGLN2JAK1 | |
| SCHEMBL13504479 | 0.83 | JAK2 (0.44) | JAK2JAK3PTK2EGLN2JAK1 | |
| SCHEMBL3304793 | 0.81 | JAK2 (0.44) | JAK2JAK3PTK2BTKUSP30 | |
| SCHEMBL3304788 | 0.81 | JAK2 (0.44) | JAK2JAK3PTK2BTKUSP30 | |
| SCHEMBL3302958 | 0.81 | USP30 (0.50) | JAK2JAK3BTKUSP30PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |
| US-8299056-B2 | Aminotriazolopyridines, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-10-30 | — | — | US | disclosed |