SCHEMBL13504841

SCHEMBL13504841

CC(C)(C)OC(=O)ON1CC=C(c2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)nccn23)CC1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TNK2 Q07912 19/20 0.78
BTK Q06187 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4361853 0.87 TNK2 (1.00) TNK2BTK
SCHEMBL13505041 0.80 TNK2 (0.75) TNK2BTK
SCHEMBL4358150 0.75 TNK2 (1.00) TNK2BTK
SCHEMBL31113436 0.73 TNK2 (0.69) TNK2BTK
SCHEMBL1128954 0.72 TNK2 (0.68) TNK2
SCHEMBL13504832 0.72 TNK2 (1.00) TNK2BTK
SCHEMBL4358059 0.72 TNK2 (1.00) TNK2BTK
SCHEMBL4352047 0.71 TNK2 (1.00) TNK2BTK
SCHEMBL4365318 0.71 TNK2 (1.00) TNK2BTK
SCHEMBL1129517 0.70 TNK2 (1.00) TNK2BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2283020-B1 SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES OSI PHARM INC (US) 2012-10-31 EP claimed