Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 12/20 | 0.75 |
| ▸ | HHAT | Q5VTY9 | 4/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12312693 | 1.00 | CYP2D6 (0.75) | CYP2D6HHATMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL12312854 | 0.93 | CYP2D6 (0.75) | CYP2D6HHATMTNR1BALDH1A1LMNA | |
| SCHEMBL13507861 | 0.93 | CYP2D6 (0.75) | CYP2D6HHATMTNR1BALDH1A1LMNA | |
| SCHEMBL12312895 | 0.89 | CYP2D6 (0.59) | CYP2D6HHATMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL12312472 | 0.89 | CYP2D6 (0.81) | CYP2D6HHAT | |
| SCHEMBL12312752 | 0.87 | CYP2D6 (0.79) | CYP2D6HHATALDH1A1LMNANPC1 | |
| SCHEMBL12312759 | 0.87 | CYP2D6 (0.78) | CYP2D6HHAT | |
| SCHEMBL2795004 | 0.86 | CYP2D6 (1.00) | CYP2D6HHAT | |
| SCHEMBL12312870 | 0.85 | CYP2D6 (0.54) | CYP2D6HHATMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL12312872 | 0.85 | CYP2D6 (0.54) | CYP2D6HHATMTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149560-A1 | 1-SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND | Astellas Pharma Inc. (JP) | 2010-02-03 | — | — | EP | disclosed |