Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 13/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683369 | 1.00 | PPARD (0.42) | PPARDPTPN1ALDH1A1GAAPPARA | |
| SCHEMBL13508271 | 0.95 | PPARD (0.42) | PPARDPTPN1ALDH1A1GAAPPARA | |
| SCHEMBL3682400 | 0.95 | PPARD (0.42) | PPARDPTPN1ALDH1A1GAAPPARA | |
| SCHEMBL13508354 | 0.91 | PTPN1 (0.45) | PPARDPTPN1GAAPPARAPPARG | |
| SCHEMBL3691327 | 0.90 | PPARD (0.47) | PPARDPTPN1PPARAPPARGCA12 | |
| SCHEMBL13508270 | 0.90 | PPARD (0.47) | PPARDPTPN1PPARAPPARGCA12 | |
| SCHEMBL13508254 | 0.88 | PPARD (0.53) | PPARDPPARAPPARGPTGDR2 | |
| SCHEMBL3691720 | 0.88 | PPARD (0.53) | PPARDPPARAPPARGPTGDR2 | |
| SCHEMBL3693445 | 0.88 | PTGDR2 (0.42) | PPARDPTPN1PPARAPPARGPTGDR2 | |
| SCHEMBL13508273 | 0.88 | PTGDR2 (0.42) | PPARDPTPN1PPARAPPARGPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| EP-1597248-B1 | SULFONAMIDE DERIVATIVES AS PPAR MODULATORS | LILLY CO ELI (US) | 2007-12-26 | — | — | EP | disclosed |