Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CMA1 | P23946 | 6/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.51 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686782 | 0.86 | NPSR1 (0.62) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL2953838 | 0.85 | NPSR1 (0.60) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL3688033 | 0.84 | CMA1 (0.59) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL13508312 | 0.83 | NPSR1 (0.58) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL3694228 | 0.83 | CMA1 (0.58) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL13508317 | 0.83 | NPSR1 (0.58) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL13509384 | 0.81 | NPSR1 (0.56) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL3680145 | 0.79 | NPSR1 (0.69) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL13508281 | 0.79 | NPSR1 (0.59) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL3686019 | 0.78 | NPSR1 (0.58) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| EP-1597248-B1 | SULFONAMIDE DERIVATIVES AS PPAR MODULATORS | LILLY CO ELI (US) | 2007-12-26 | — | — | EP | disclosed |