Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.60 |
| ▸ | EGFR | P00533 | 4/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | MST1R | Q04912 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.60 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | HGF | P14210 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863116 | 0.95 | AXL (0.63) | METEGFRKDRMST1RAURKA | |
| SCHEMBL15404688 | 0.93 | AXL (0.60) | METEGFRKDRMST1RAURKA | |
| SCHEMBL15404499 | 0.93 | FLT3 (0.63) | METEGFRKDRMST1RAURKA | |
| SCHEMBL13511915 | 0.92 | AXL (0.59) | METEGFRKDRMST1RAURKA | |
| SCHEMBL13511929 | 0.92 | AXL (0.59) | METEGFRKDRMST1RAURKA | |
| SCHEMBL13511920 | 0.91 | AXL (0.59) | METEGFRKDRMST1RAURKA | |
| SCHEMBL2861493 | 0.91 | AXL (0.62) | METEGFRKDRMST1RAURKA | |
| SCHEMBL13511936 | 0.90 | AXL (0.63) | METEGFRKDRMST1RAURKA | |
| SCHEMBL13511919 | 0.89 | AXL (0.61) | METEGFRKDRMST1RAURKA | |
| SCHEMBL13511913 | 0.89 | AXL (0.61) | METEGFRKDRMST1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-B1 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-7652009-B2 | Substituted heterocycles and methods of use | AMGEM INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652009-B2 | Substituted heterocycles and methods of use | AMGEM INC. (US) | 2010-01-26 | — | — | US | disclosed |