Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | CASP1 | P29466 | 5/20 | 0.47 |
| ▸ | CASP7 | P55210 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | GLA | P06280 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.46 |
| ▸ | PDE8B | O95263 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522639 | 0.91 | KDM4E (0.51) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL14944605 | 0.87 | TLR7 (0.44) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL13522641 | 0.83 | TLR7 (0.49) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL7206462 | 0.83 | TLR7 (0.48) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL7204717 | 0.83 | TLR7 (0.57) | TLR7 | |
| SCHEMBL14944574 | 0.83 | TLR7 (0.46) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL3137649 | 0.79 | TLR7 (0.45) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL7209281 | 0.79 | TLR7 (0.60) | TLR7 | |
| SCHEMBL7204280 | 0.78 | TLR7 (0.61) | TLR7 | |
| SCHEMBL7205129 | 0.77 | TLR7 (0.65) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642350-B2 | Purine derivatives | PFIZER LIMITED (GB) | 2010-01-05 | — | — | US | disclosed |
| US-7642350-B2 | Purine derivatives | PFIZER LIMITED (GB) | 2010-01-05 | — | — | US | disclosed |