Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168625 | 0.84 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL3168611 | 0.84 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL3176429 | 0.84 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL3176416 | 0.84 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL6677087 | 0.82 | MEN1 (0.71) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1019784 | 0.82 | MEN1 (0.71) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL13524148 | 0.82 | MAPT (0.67) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL2687117 | 0.82 | MEN1 (0.71) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL706409 | 0.81 | MAPT (0.56) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL6172741 | 0.81 | BACE1 (0.68) | MEN1KMT2AALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |