Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.72 |
| ▸ | KDR | P35968 | 7/20 | 0.72 |
| ▸ | BRAF | P15056 | 5/20 | 0.72 |
| ▸ | RET | P07949 | 4/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.72 |
| ▸ | ABL1 | P00519 | 3/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.72 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.72 |
| ▸ | SRC | P12931 | 3/20 | 0.72 |
| ▸ | PLK4 | O00444 | 2/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.72 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.72 |
| ▸ | LCK | P06239 | 2/20 | 0.72 |
| ▸ | FYN | P06241 | 2/20 | 0.72 |
| ▸ | LYN | P07948 | 2/20 | 0.72 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.72 |
| ▸ | AXL | P30530 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10201086 | 0.92 | RAF1 (0.73) | RAF1KDRBRAFRETMAPK14 | |
| SCHEMBL22594900 | 0.88 | RAF1 (0.75) | RAF1KDRBRAFRETMAPK14 | |
| SCHEMBL10324287 | 0.88 | RAF1 (0.75) | RAF1KDRBRAFRETMAPK14 | |
| SCHEMBL257980 | 0.87 | RAF1 (0.82) | RAF1KDRBRAFRETMAPK14 | |
| SCHEMBL16620832 | 0.86 | RAF1 (0.74) | RAF1KDRBRAFRETMAPK14 | |
| SCHEMBL14481178 | 0.85 | RAF1 (0.71) | RAF1KDRBRAFRETMAPK14 | |
| Sorafenib SCHEMBL15921371 | 0.85 | RAF1 (0.93) | RAF1KDRBRAFRETMAPK14 | |
| SCHEMBL12500806 | 0.84 | RAF1 (0.73) | RAF1KDRBRAFRETMAPK14 | |
| Sorafenib SCHEMBL8218 | 0.84 | RAF1 (1.00) | RAF1KDRBRAFRETMAPK14 | |
| Sorafenib SCHEMBL29349634 | 0.84 | RAF1 (1.00) | RAF1KDRBRAFRETMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | BOOJAMRA CONSTANTINE G | 2010-01-28 | — | — | US | disclosed |
| US-20090181930-A1 | KINASE INHIBITORY PHOSPHONATE ANALOGS | CANNIZZARO CARINA | 2009-07-16 | — | — | US | disclosed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7417055-B2 | Kinase inhibitory phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181930-A1 | KINASE INHIBITORY PHOSPHONATE ANALOGS | PIK3CA, PNKP, PIK3CB | RAF1 320/4885KDR 860/4885BRAF 378/4885 |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | PIK3CA, PHOSPHO1, PTEN | RAF1 1304/4885KDR 1628/4885BRAF 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.