Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.70 |
| ▸ | JAK2 | O60674 | 12/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13535427 | 0.92 | JAK1 (0.68) | JAK1JAK2 | |
| SCHEMBL13535405 | 0.87 | JAK1 (0.72) | JAK1JAK2 | |
| SCHEMBL13535530 | 0.87 | JAK1 (0.82) | JAK1JAK2 | |
| SCHEMBL13535386 | 0.87 | JAK1 (0.72) | JAK1JAK2 | |
| SCHEMBL13535479 | 0.86 | JAK1 (0.71) | JAK1JAK2 | |
| SCHEMBL13535559 | 0.85 | JAK1 (0.73) | JAK1JAK2ABL1 | |
| SCHEMBL13535674 | 0.85 | JAK1 (0.65) | JAK1JAK2 | |
| SCHEMBL3266576 | 0.85 | JAK1 (0.70) | JAK1JAK2 | |
| SCHEMBL24062654 | 0.84 | JAK1 (0.80) | JAK1JAK2 | |
| SCHEMBL13535464 | 0.84 | JAK1 (0.68) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |